Using multiple templates to improve quality of homology models in automated homology modeling
نویسندگان
چکیده
منابع مشابه
Using multiple templates to improve quality of homology models in automated homology modeling.
When researchers build high-quality models of protein structure from sequence homology, it is today common to use several alternative target-template alignments. Several methods can, at least in theory, utilize information from multiple templates, and many examples of improved model quality have been reported. However, to our knowledge, thus far no study has shown that automatic inclusion of mu...
متن کاملAutomated multiple analysis of protein structures: application to homology modeling of cytochromes P450.
A computational strategy for homology modeling, using several protein structures comparison, is described. This strategy implies a formalized definition of structural blocks common to several protein structures, a new program to compare these structures simultaneously, and the use of consensus matrices to improve sequence alignment between the structurally known and target proteins. Applying th...
متن کاملRelative (co)homology of $F$-Gorenstein modules
We investigate the relative cohomology and relative homology theories of $F$-Gorenstein modules, consider the relations between classical and $F$-Gorenstein (co)homology theories.
متن کاملUsing Phylogeny to Improve Genome-Wide Distant Homology Recognition
The gap between the number of known protein sequences and structures continues to widen, particularly as a result of sequencing projects for entire genomes. Recently there have been many attempts to generate structural assignments to all genes on sets of completed genomes using fold-recognition methods. We developed a method that detects false positives made by these genome-wide structural assi...
متن کاملHLA-Modeler: Automated Homology Modeling of Human Leukocyte Antigens
The three-dimensional (3D) structures of human leukocyte antigen (HLA) molecules are indispensable for the studies on the functions at molecular level. We have developed a homology modeling system named HLA-modeler specialized in the HLA molecules. Segment matching algorithm is employed for modeling and the optimization of the model is carried out by use of the PFROSST force field considering t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Protein Science
سال: 2008
ISSN: 0961-8368,1469-896X
DOI: 10.1110/ps.073344908